Patrick Dolan

Patrick T. Dolan, Ph.D. is a virologist and computational biologist in the Department of Microbiology and Immunology at the University of California, San Francisco.

Early life and education
Patrick Dolan was born in 1985 in Midland, Michigan. He attended Herbert Henry Dow High School and graduated with a B.S. in Microbiology and Molecular Genetics from Michigan State University in 2007. Patrick earned his Ph.D. in Biological Sciences in 2014 from Purdue University, his dissertation was titled "Analysis of Hepatitis C Virus-Host Protein Interaction Network". He then performed post-doctoral studies focused on the evolution of with Judith Frydman at Stanford University and Raul Andino at University of California, San Francisco.

Research
Patrick Dolan's research focuses on the co-evolution of viruses and their hosts.

Notable publications
Dolan PT, Taguwa S, Rangel MA, Acevedo A, Hagai T, Andino R, Frydman J. Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells. Elife. 2021 Jan 25;10. doi: 10.7554/eLife.61921. PubMed PMID: 33491648.

Dolan PT, Whitfield ZJ, Andino R. Mapping the Evolutionary Potential of RNA Viruses. Cell Host Microbe. 2018 Apr 11;23(4):435-446. doi: 10.1016/j.chom.2018.03.012. Review. PubMed PMID: 29649440; PubMed Central PMCID: PMC5908228.

Xiao Y*, Dolan PT*, Goldstein EF, Li M, Farkov M, Brodsky L, Andino R. Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses. Nat Commun. 2017 Aug 29;8(1):375. doi: 10.1038/s41467-017-00354-5. PubMed PMID: 28851882; PubMed Central PMCID: PMC5575128. *co-authored

Dolan PT, Roth AP, Xue B, Sun R, Dunker AK, Uversky VN, LaCount DJ. Intrinsic disorder mediates hepatitis C virus core-host cell protein interactions. Protein Sci. 2015 Feb;24(2):221-35. doi: 10.1002/pro.2608. Epub 2014 Dec 31. PubMed PMID: 25424537; PubMed Central PMCID: PMC4315660.